Cerebrospinal Fluid Biomarker for Alzheimer Disease Predicts Postoperative Cognitive Dysfunction

L Evered; B Silbert; DA Scott; D Ames; P Maruff; K Blennow

Journal article

Cerebrospinal Fluid Biomarker for Alzheimer Disease Predicts Postoperative Cognitive Dysfunction

L Evered, B Silbert, DA Scott, D Ames, P Maruff, K Blennow

Anesthesiology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2016

DOI: 10.1097/ALN.0000000000000953

Abstract

Background: Postoperative cognitive dysfunction (POCD) affects 16 to 21% of the elderly 3 months after anesthesia and surgery and is associated with adverse outcomes. The exact cause of POCD remains unknown. The authors hypothesized that elderly individuals with Alzheimer disease (AD) neuropathology, identified by cerebrospinal fluid (CSF) analysis, would have increased the risk for POCD. Methods: CSF samples were collected from 59 patients 60 yr or older who received combined spinal and general anesthesia for elective total hip replacement. Patients underwent neuropsychological testing preoperatively and at 7 days, 3 months, and 12 months postoperatively. POCD at 3 months and cognitive decl..

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University of Melbourne Researchers

Lis Evered Author

Brendan Silbert Author

David Ames Author

Paul Maruff Author

Related Projects (1)

How anaesthesia effects mental function

It is known that about 10% of patients over the age of 55 have difficulty with cognition and thinking 3 months after surgery and anaesthesia..

Grants

Awarded by Australian National Health and Medical Research Council, Australian Capital Territory, Canberra, Australia

Funding Acknowledgements

This study was supported by the Australian National Health and Medical Research Council, Australian Capital Territory, Canberra, Australia (project grant no. 454440); the Australian and New Zealand College of Anaesthetists (Melbourne, Australia) Research grant; the Torsten Soderberg Foundation at the Royal Swedish Academy of Sciences (Stockholm, Sweden); and the Research Council (Stockholm, Sweden).